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Determination of tacrine and its 1-hydroxy metabolite in plasma using column liquid chromatography with ultraviolet detection
Summary
Type:
HPLC
Application #:
104810
Catalog#:
720120.46 - MN HPLC Column, Nucleosil C18, 100A, 5um, 4.6x150mm
Detection:
UV, 240nm
Conditions:
eluent: acetonitrile - 0.02M phosphate buffer pH 2.7 (15:85, v/v)
flow rate 1.1ml/min
Authors:
Ekman L
Source:
J Chromatogr 494 (1989) 397 - 402
Details
Legend: Fig. 3. Left: chromatogram of blank plasma, centre: chromatogram of plasma spiked with 30ng/ml THA-1-ol, right: sample from a patient containing 10ng/ml THA and 130ng/ml THA-1-ol.
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